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目的分析靖江市人民医院药品不良反应(ADR)的特点,为临床合理用药提供参考。方法收集上报的ADR报告1137例,采用Pareto最优分析法,从患者年龄、药物品种、抗菌药物品种、给药途径以及严重ADR进行分析和归纳。结果 1137例中,ADR患者主要年龄段在41~70岁及10岁以内,尤其是61~70岁的患者,占ADR的18.21%;涉及药物种类主要为抗菌药物,占ADR的41.54%;主要给药途径为静脉滴注,占ADR的78.56%;发生严重ADR 78例(6.86%),经减量或停药,及对症处理后,患者好转或治愈,无死亡病例。结论应加强对患者的用药监护,尤其是特殊人群、抗菌药物及静脉用药的管理,减少ADR的发生,确保临床用药安全、有效。
Objective To analyze the characteristics of adverse drug reaction (ADR) in Jingjiang People’s Hospital and provide reference for clinical rational drug use. Methods A total of 1137 reported cases of ADR were collected and analyzed by Pareto optimal analysis, including age, drug varieties, antibacterials, route of administration and severe ADR. Results In 1137 cases, ADR patients were mainly aged from 41 to 70 years and within 10 years of age, especially from 61 to 70 years old, accounting for 18.21% of ADR. Antibiotics were mainly involved in antimicrobial drugs, accounting for 41.54% of ADR; The route of administration was intravenous drip, accounting for 78.56% of ADRs; 78 cases (6.86%) of ADRs were serious, no cases of death occurred after reduction or withdrawal and symptomatic treatment. Conclusion It is necessary to strengthen the patient medication monitoring, especially the special population, antimicrobial drugs and intravenous drug administration, reduce the occurrence of ADR, to ensure the clinical medication safe and effective.