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对符合GBZ70—2002《尘肺病诊断标准》的22例0+、Ⅰ、Ⅱ期尘肺住院患者进行肺灌洗,所得肺灌洗液分瓶进行细胞计数,再混合浓缩,ELISA检测CC-10及ΤNF-α的含量。3个期别煤工尘肺灌洗液中第2、3瓶的细胞数最多。随着期别的增加,煤工尘肺灌洗液中CC-10、TNF-α含量均明显降低,P<0.01。检测结果表明,煤尘对Clara细胞的损伤及肺泡内巨噬细胞的凋亡情况,对临床治疗具有重要的指导意义。
Twenty-two patients with stage 0 +, stage I, and stage II pneumoconiosis who met GBZ70-2002 “Diagnostic criteria for pneumoconiosis” were subjected to lung lavage. The lung lavage fluid was divided into bottles for cell counting, and then mixed and concentrated. The levels of CC-10 and TnF-α content. The first and second bottles of coal miners’ pneumoconiosis lavage fluid in the three phases had the highest number of cells. With the increase of stage, the contents of CC-10 and TNF-αin coal miners pneumoconiosis lavage fluid decreased obviously, P <0.01. The test results show that the injury of Clara cells and the apoptosis of alveolar macrophages in coal dust have important guiding significance for clinical treatment.