急性酒精性肝炎(AAH)在前4周内死亡率高达60％,其后存活患者中半数以上可发生肝硬化。AAH患者用亲肝因子可降低近期死亡率,说明肝再生能力可影响临床预后。肝细胞生长因子(HGF)与α-转化生长因子(TGFα)均是肝细胞增生的强力刺激物,而TGFβ_1是肝细胞增生抑制剂,对肝纤维发生亦是一种强力 Acute alcoholic hepatitis (AAH) has a mortality rate of up to 60% within the first 4 weeks and more than half of all surviving patients can develop cirrhosis of the liver. AAH patients with pro-liver factor can reduce the recent mortality, indicating that liver regeneration can affect the clinical prognosis. Hepatocyte growth factor (HGF) and α-transforming growth factor (TGFα) are potent stimulators of hepatocyte proliferation, whereas TGFβ_1 is a hepatocyte proliferation inhibitor that is also a potent inhibitor of hepatic fibrosis