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目的观察角膜缘干细胞移植和生物羊膜移植治疗翼状胬肉的临床疗效。方法将58例(66眼)随机分为2组,分别采用角膜缘干细胞移植32例(36眼)和生物羊膜移植26例(30眼),术后随访6个月～2年。结果角膜缘干细胞移植组复发1眼,复发率2.78%,生物羊膜移植组复发7眼,复发率23.33%。两组比较差异有统计学意义。角膜创面愈合时间:角膜缘干细胞组1～3d,平均为(1.85±0.95)d,生物羊膜组2～5d,平均为(3.36±1.65)d。结论带角膜缘干细胞移植和生物羊膜移植术治疗翼状胬肉都能取得良好效果,但带角膜缘干细胞移植比生物羊膜移植角膜创面修复快,复发率低。
Objective To observe the clinical effects of limbal stem cell transplantation and amniotic membrane transplantation for the treatment of pterygium. Methods Fifty-six cases (66 eyes) were randomly divided into two groups. 32 cases (36 eyes) were limbal stem cell transplantation and 26 cases (30 eyes) were treated by biological amniotic membrane transplantation. The patients were followed up for 6 months to 2 years. Results In the limbal stem cell transplantation group, one case had a recurrence rate of 2.78%. Seven cases were found in the amniotic membrane transplantation group, with a recurrence rate of 23.33%. The difference between the two groups was statistically significant. Corneal wound healing time: limbal stem cell group 1 ~ 3d, an average of (1.85 ± 0.95) d, biological amnion group 2 ~ 5d, an average of (3.36 ± 1.65) d. Conclusions Both limbal stem cell transplantation and biological amniotic membrane transplantation can achieve good results in the treatment of pterygium. However, limbal stem cell transplantation with limbal stem cell transplantation is faster than that with biological amniotic membrane transplantation, and the recurrence rate is low.