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目的分析肠道病毒71型(enterovirus 71,EV71)抗体阳性的手足口病患儿免疫球蛋白、血糖、脑脊液的检测结果,探讨其临床意义。方法选取胶体金法检测EV71-IgM阳性、阴性的手足口病患儿各50例,行血清免疫球蛋白、血糖及脑脊液检查,采用SPSS 12.5软件统计分析2组病例各项实验指标的差异。结果 50例EV71抗体阳性组患儿血清免疫球蛋白IgA、IgG、IgM分别为(0.52±0.38)、(8.36±2.15)和(1.52±0.26)g/L,50例EV71抗体阴性组患儿血清免疫球蛋白IgA、IgG、IgM分别为(0.41±0.21)、(8.45±2.34)和(1.48±0.27)g/L,2组比较,差异无统计学意义(P>0.05)。50例EV71抗体阳性患儿中有26例血糖升高,血糖升高率为52.0%;22例脑脊液检查异常,脑脊液检查异常率为44.0%。而50例EV71抗体阴性组患儿中有4例血糖升高,血糖升高率为8.0%;3例脑脊液检查异常,脑脊液检查异常率为6.0%。2组比较,差异均有统计学意义(均P<0.05)。结论在手足口病患儿中开展EV71抗体的检测同时检测患儿血糖和脑脊液有助于危重患儿的早期诊断和治疗。
Objective To analyze the detection results of immunoglobulin, blood glucose and cerebrospinal fluid (CSF) in children with hand-foot-mouth disease with enterovirus 71 (EV71) antibody and to explore its clinical significance. Methods 50 cases of EV71-IgM positive and negative hand-foot-mouth disease were detected by colloidal gold method. Serum immunoglobulin, blood glucose and cerebrospinal fluid (CSF) were examined. SPSS 12.5 software was used to analyze the difference of each experimental index. Results Serum immunoglobulin IgA, IgG and IgM in 50 EV71 positive patients were (0.52 ± 0.38), (8.36 ± 2.15) and (1.52 ± 0.26) g / L, respectively, and 50 EV71 antibody negative patients Immunoglobulin IgA, IgG and IgM were (0.41 ± 0.21), (8.45 ± 2.34) and (1.48 ± 0.27) g / L, respectively. There was no significant difference between the two groups (P> 0.05). In 50 EV71 antibody-positive children, 26 cases had hyperglycemia and the rate of hyperglycemia was 52.0%. Twenty-two patients had cerebrospinal fluid abnormalities and CSF abnormalities was 44.0%. In 50 EV71 antibody-negative children, 4 cases had hyperglycemia and 8.0% increase in blood sugar. Three cases of cerebrospinal fluid abnormalities and CSF abnormalities were 6.0%. The differences between the two groups were statistically significant (both P <0.05). Conclusion The detection of EV71 antibodies in children with HFMD and the detection of blood sugar and cerebrospinal fluid in children are helpful for the early diagnosis and treatment of critically ill children.