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在原发性肾小球疾病中,普遍存在蛋白尿,其中部分为免疫球蛋白(Ig)。本文根据对80例原发性肾小球疾病患者尿中IgG(其中49例同时测定尿IgG、IgA、IgM)的测定结果,初步分析尿Ig的检测对原发性肾小球疾病的发病机理、诊断及预后的意义。病例选择及方法病例选择:按1985年南京第二届全国肾脏病学术会议关于肾小球疾病临床分型标准。80例原发性肾炎病中:急性肾小球肾炎16例,慢性肾小球肾炎19例,肾病综合征Ⅰ型4例,Ⅱ型35例,隐匿性肾小球疾病6例。方法:收集夜间8小时尿,于晨间立即送检,将尿浓缩至原尿的1/10～1/15,用单向免疫扩散法,同时测定尿和血的Ig。
In primary glomerular disease, proteinuria is prevalent, some of which are immunoglobulins (Ig). This article based on 80 cases of primary glomerular disease in patients with urinary IgG (49 cases of simultaneous determination of urinary IgG, IgA, IgM) results of the initial analysis of urinary Ig detection of primary glomerular disease pathogenesis , The significance of diagnosis and prognosis. Case Selection and Method Case Selection: According to the Second National Symposium on Nephrology in Nanjing in 1985 on the clinical classification of glomerular disease. 80 cases of primary nephritis disease: 16 cases of acute glomerulonephritis, 19 cases of chronic glomerulonephritis, nephrotic syndrome type Ⅰ 4 cases, 35 cases of type Ⅱ, occult glomerular disease in 6 cases. Methods: Urine was collected at night for 8 hours. The urine was collected immediately at morning. The urine was concentrated to 1/10 ~ 1/15 of the original urine. One-way immunodiffusion was used to determine urinary and blood Ig simultaneously.