本文着重讨论了经血管介入的预测自动推药动物实验,研究了动物实验中存在的参数时变性与个体差异性,改进、完善了体外脉动流模拟实验中的模型和算法,增强了模型的时变适应性及容错性。实验结果表明,在心舒张期推药较之收缩期推药,靶目标血药浓度更高;经改进的与心动周期同步的预测控制推药方法,可进入临床试验。 This article focuses on the prediction of auto-drug-induced animal experiments by vascular intervention, studies the time-varying and individual differences existing in animal experiments, improves and perfects the model and algorithm in in vitro pulsatile flow simulation experiments, enhances the model’s time Adaptability and fault tolerance. Experimental results show that in the cardiac diastolic push than systolic push drug target plasma concentration higher; improved and synchronized with the cardiac cycle control method of predictive control can enter the clinical trial.