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报道了低剂量γ线照射复合苯诱发家兔血淋巴细胞和骨髓细胞遗传效应的实验研究。结果表明:苯和γ线都能诱发染色体畸变和SCE频率的升高;畸变类型主要是染色体型无着丝粒断片;血淋巴细胞染色体畸变率要比骨髓细胞的高;随剂量的变化,γ线诱发染色体畸变的升高比诱发SCE的要明显得多,但剂量效应线性相关不明显,相反,苯诱发SCE的升高要比诱发染色体畸变的要明显,且血淋巴细胞无着丝粒畸变率和SCE频率与剂量呈线性相关。染色体畸变效应总的趋势是:高复组>低复组>照射组>高苯组>低苯组>对照组;苯能提高γ线诱发的染色体畸变率,在双+环主要是协同,而在无着丝粒主要是相加。
The experimental study on the genetic effects of low-dose γ-ray irradiated compound benzene-induced rabbit lymphocytes and bone marrow cells was reported. The results showed that both benzene and γ-rays could induce chromosomal aberrations and increase in SCE frequency; the types of aberrations were mainly chromosomal asymmetric centromeres; the chromosome aberration rate of blood lymphocytes was higher than that of bone marrow cells; as the dose changed, γ The increase of chromosomal aberration induced by line was much more obvious than that induced by SCE, but the dose-response linear correlation was not obvious. On the contrary, the increase of benzene-induced SCE was more obvious than that induced by chromosomal aberration, and there was no centripetal aberration in blood lymphocytes. Rates and SCE frequency are linearly related to dose. The general trend of chromosomal aberration effects was: high-fuction group> low-complex group> irradiation group> high-benzene group> low-benzene group> control group; benzene could increase the chromosomal aberration rate induced by gamma rays, and was mainly synergistic in the double + ring. In the absence of centromeres, the sum is mainly added.