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本文试图从细胞水平上探讨毛冬麦甲素对心肌的作用机理。实验取豚鼠右心室乳头肌作离体恒速灌流,用电驱动诱发其动作电位,以玻璃微电极引导,观察动作电位复极化时程和有效不应期等变化。实验结果表明:毛冬青甲素有延长APD50、APD_(90)和ERP的作用;硝苯吡啶能全部阻断毛冬青甲素延长APD和ERP的效应:酚妥拉明能使毛冬青甲素的效应减弱;心得安基本不影响毛冬青甲素延长APD和ERP的作用.提示毛冬青甲素主要通过激活钙通道,促进Ca~(++)内流起作用;其作用可能与α受体有关,但与β受体基本无关.
This article attempts to explore the mechanism of the action of triamcinolone on the myocardium at the cellular level. The guinea pig right ventricle papillary muscles were used for constant perfusion perfusion in vitro. The action potentials were induced by electric driving and guided by glass microelectrodes. The repolarization duration and effective refractory period of action potentials were observed. The experimental results show that: Mao Dongqing A has the effect of prolonging APD50, APD_(90) and ERP; nifedipine can completely block the effect of prolonged APD and ERP by Maodongqing A: phentolamine can make Mao Dongqing A The effect is weakened; propranolol does not substantially affect the effect of prolonged APD and ERP by Maodongqing A. It is suggested that Maodongqingsu plays an important role in Ca(++) influx through activation of calcium channel; its effect may be related to α receptors. , but has nothing to do with beta receptors.