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孤核受体NR4A1(nuclear receptor subfamily4,group A,member 1)是核受体超家族中的一员,在多种细胞中表达,同时功能十分广泛,不仅参与细胞周期调控(增殖或凋亡),还与神经性疾病、类固醇激素的生成、肿瘤以及动脉粥样硬化的形成及能量调控密切相关。近年来,NR4A1与能量代谢的关系逐渐引起人们的广泛关注,在能量平衡调控中发挥了重要作用。
Nuclear receptor subfamily 4 (group A, member 1), a member of the nuclear receptor superfamily, is expressed in a wide range of cells and has a wide range of functions not only involved in cell cycle regulation (proliferation or apoptosis) , But also with neurological diseases, steroid hormone production, tumor and atherosclerosis formation and energy regulation is closely related. In recent years, the relationship between NR4A1 and energy metabolism gradually attracted people’s attention, and played an important role in energy balance regulation.