中枢神经系统的损害是随着铅吸收量的增加而加剧,但是至今还缺乏特定的和灵敏的神经化学和(或)生物化学的指标,以观察铅对中枢神经系统的作用。同时还由于铅与锌在自然界常常共存,因此作者分别测定了铅、锌以及观察铅锌对脑中某些神经传导介质含量的影响,藉以获得这些金属对铅锌矿工人作用的资料,同时也为铅引起的脑病和神经精神性后遗症提供了神经药理学的根据。作者将体重在100～125g之间的24只雄 Damage to the central nervous system is exacerbated by increased levels of lead uptake, but so far there is a lack of specific and sensitive neurochemical and / or biochemical indicators to observe lead’s effects on the central nervous system. At the same time, because lead and zinc frequently coexist in nature, the authors determined the effects of lead and zinc on the contents of some neurotransmitters in the brain, respectively, so as to obtain information on the role of these metals in lead-zinc miners. It provides a neuropsychological basis for lead-induced encephalopathy and neuropsychiatric sequelae. The author will weigh between 100 ~ 125g of 24 male