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目的探讨血清降钙素原(PCT)、超敏C反应蛋白(hs CRP)和白细胞计数(WBC)在小儿呼吸道感染病原诊断中的价值。方法选取广东省中医院儿科143例呼吸道感染患儿作为研究对象,按感染病原分为病毒组(42例)、支原体组(45例)和细菌组(56例)。其中细菌组包括革兰阳性(G~+)菌组27例,革兰阴性(G~-)菌组29例。分别检测各组血清PCT、hsCRP及WBC,并进行统计学分析。结果细菌组PCT、hsCRP及WBC水平均明显高于病毒组和支原体组(P<0.05),G~-菌组PCT水平明显高于G~+菌感染组(P<0.01)。PCT用于诊断细菌感染和G-菌感染的ROC曲线下面积大于hsCRP和WBC。结论PCT、hsCRP和WBC检测可初步判断小儿呼吸道疾病病原类型且PCT的诊断价值优于hsCRP和WBC。
Objective To investigate the value of serum procalcitonin (PCT), high-sensitivity C-reactive protein (hs CRP) and white blood cell count (WBC) in the diagnosis of pediatric respiratory tract infection. Methods A total of 143 pediatric patients with respiratory tract infection were selected as subjects in the pediatric department of Guangdong Provincial Hospital of Traditional Chinese Medicine. The patients were divided into four groups according to their infectious pathogens: the virus group (42 cases), the mycoplasma group (45 cases) and the bacteria group (56 cases). The bacterial group included 27 Gram-positive (G ~ +) bacteria and 29 Gram-negative (G ~) bacteria. The serum PCT, hsCRP and WBC in each group were detected and statistically analyzed. Results The levels of PCT, hsCRP and WBC in bacterial group were significantly higher than those in virus group and mycoplasma group (P <0.05). The PCT level in G ~ - bacteria group was significantly higher than that in G ~ + group (P <0.01). The area under the ROC curve of PCT for the diagnosis of bacterial infections and G-infections was greater than hsCRP and WBC. Conclusion The PCT, hsCRP and WBC tests can be used to determine the pathogenic types of respiratory diseases in children and the diagnostic value of PCT is better than hsCRP and WBC.