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目的:探讨益气活血法降低D-Dimer、HSP70高表达对急性缺血性脑卒中(AIS)临床症状的改善作用。方法:将46例AIS受试者随机分为两组,对照组23例予西医常规治疗,治疗组23例在西医常规治疗基础上加用黄芪注射液合灯盏细辛注射液;疗程5d。比较两组的总有效率及两组治疗前、治疗后不同时点(第1、3、5天)D-Dimer、HSP70、美国国立卫生研究院卒中量表(NIH Stroke Scale,NIHSS)评分、中风证候积分的差别。结果:①两组治疗总有效率比较,差异无统计学意义(P>0.05)。②NIHSS评分:对照组治疗后第3、5天评分与治疗前比较,差异有统计学意义(P<0.05);治疗组治疗后第1、3、5天评分与治疗前比较,差异有统计学意义(P<0.05);两组治疗后第3天比较,差异有统计学意义(P<0.05)。③中医证候积分:对照组治疗后第3、5天评分与治疗前比较,差异有统计学意义(P<0.05);治疗组治疗后第1、3、5天评分与治疗前比较,差异均有统计学意义(P<0.05);两组治疗后第1、3、5天比较,差异均有统计学意义(P<0.01)。④微循环指标:各组内治疗前后D-Dimer、HSP70比较,差异有统计学意义(P<0.05);治疗组治疗后D-Dimer、HSP70的改善优于对照组,差异有统计学意义(P<0.05)。结论:在西医常规治疗基础上联合应用益气活血法,可明显降低D-Dimer、HSP70高表达,改善AIS微循环障碍并促进神经功能缺损的修复,从而显著降低AIS患者NIHSS评分与中医证候积分,改善患者临床症状。
Objective: To investigate the effects of Yiqihuoxue method on reducing the clinical symptoms of acute ischemic stroke (AIS) by increasing D-Dimer and HSP70 overexpression. Methods: Forty-six AIS subjects were randomly divided into two groups. The control group (23 cases) received conventional treatment of Western medicine. The treatment group (23 cases) received Astragalus injection combined with Erigeron breviscapus injection on the basis of routine treatment of Western medicine. The course of treatment was 5 days. The total effective rate was compared between the two groups before and after treatment, D-Dimer, HSP70, NIH Stroke Scale (NIHSS) scores at different time points after treatment (days 1, 3 and 5) Stroke syndrome score difference. Results: ① The total effective rate of the two groups was no significant difference (P> 0.05). ②NIHSS score: the score of the control group on the 3rd and 5th day after treatment was significantly lower than that before treatment (P <0.05); the scores of the 1st, 3rd, 5th day after treatment in the treatment group were statistically different from those before treatment (P <0.05). There was a significant difference between the two groups on the third day after treatment (P <0.05). (3) TCM Syndrome Score: The score of the control group on the 3rd and 5th day after treatment was significantly lower than that before treatment (P <0.05); the score of the 1st, 3rd, 5th day after treatment in the treatment group was significantly lower than that before treatment (P <0.05). There was a significant difference between the two groups on the 1st, 3rd and 5th day after treatment (P <0.01). ④ Microcirculation index: The D-Dimer and HSP70 in each group before and after treatment showed significant difference (P <0.05); The improvement of D-Dimer and HSP70 in the treatment group was better than that in the control group, the difference was statistically significant P <0.05). Conclusion: The combination of Yiqihuoxue therapy can significantly reduce the expression of D-Dimer and HSP70, improve the microcirculation disturbance of AIS and promote the repair of neurological deficit, thus significantly reduce NIHSS score and TCM syndromes in AIS patients Points, improve patient clinical symptoms.