论文部分内容阅读
作者对1987—1990年间CT(Computed tomogra-phy,简CT)造影液引起碘化物诱导甲状腺机能亢进(iodide-induced hyperthyroidism,IIHT)的可能性进行了研究.在此期间有24600例病人进行CT检查.在使用总剂量3—12mg静注CT造影液(碘酞六醇或甲泛影酸)后,有7例病人发展为严重性IIHT,需入院治疗(平均:甲状腺素222nmol/L,正常值为70—166nmol/L;促甲状腺素(TSH)0.06mU/L,正常值0.3—5.OmU/L).此量超出吸收碘化物最低需求量50μg/d的60—240倍.放射性碘化物中碘原子以共价键和苯环结合.这些化合物在体内不能为脱碘酶所代谢.这些造影剂在制备的过程中污染有游离的碘,其最大浓度为20μg/mL,并对甲状腺产生作用.没有一例病人以前使用过碘化物,也没有甲状腺自身抗体.7例IIHT病人中有1例患多发性结节性甲状腺肿,2例继发性肢
The authors studied the possibility of CT-induced contrast-induced hyperthyroidism (IIHT) between 1987 and 1990. During this period, 24,600 patients underwent CT examination Seven patients developed severe IIHT after a total dose of 3-12 mg intravenous CT contrast solution (iptaxol or methotrexate) was admitted to hospital (mean: thyroxine 222 nmol / L, normal (70-166nmol / L), thyroid-stimulating hormone (TSH) 0.06mU / L, normal value 0.3-5.OmU / L), which is 60-240 times higher than the 50μg / The iodine atoms are covalently bonded to the benzene ring and these compounds are not metabolized by the deiodinase in vivo.These contrast agents are contaminated with free iodine during preparation, with a maximum concentration of 20 μg / mL, None of the patients had previously used iodide and had no thyroid autoantibodies.7 One of seven IIHT patients had multiple nodular goiter and two had secondary limbs