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2,6-二叔丁基苯酚(2,6-DTBP)、3,5-二叔丁基-4-羟基苄基二甲胺(苄甲胺)、3,5-二叔丁基-4-羟基苄基膦酸二乙酯(1222)和双[3,5-二叔丁基-4-羟基苄基膦酸单乙酯]镍盐(2002)是一组酚类抗氧剂。本研究主要结果如下: (1)测定了四种化合物的急性毒性,并提出了“急性毒性指数”(LD_(50)/LD_(50)-剂量反应回归直线斜率)这一评价急性毒性的综合指标。 (2)在体内实验,四种化合物均可使大鼠和小鼠的血ChE活性增加,并通过体外实验证明,1222和2002的这种作用需要经过一定的代谢转化。 (3)短期多次给药后,四种化合物均出现鼠肝微粒体酶诱导剂的作用,其中以2,6-DTBP和苄甲胺的诱导作用较强。
Di-tert-butylphenol (2,6-DTBP), 3,5-di-tert-butyl-4-hydroxybenzyldimethylamine (benzylamine), 3,5-di- - hydroxybenzylphosphonate (1222) and bis [3,5-di-tert-butyl-4-hydroxybenzylphosphonate monoethyl ester] nickel salt (2002) are a group of phenolic antioxidants. The main results of this study are as follows: (1) The acute toxicity of four compounds was determined and the combination of acute toxicity index (LD_ (50) / LD_ (50) - dose response regression slope slope) index. (2) In vivo experiments, four compounds can increase the blood ChE activity of rats and mice, and in vitro experiments show that this effect of 1222 and 2002 need to undergo a certain degree of metabolic transformation. (3) After short-term repeated administration, all four compounds showed the effect of inducing agents of rat liver microsomes, especially 2,6-DTBP and benzylamine.