目的　观察清开灵注射液对脑血肿家兔血气值变化的影响。方法　利用自体血凝块颅内埋藏法复制家兔脑血肿模型 ,在脑血肿形成后不同时间测定血气值变化。结果　脑血肿形成后 ,动物有过度通气 ,表现为代谢性酸中毒合并呼吸性碱中毒的混合型酸碱平衡紊乱 ,清开灵治疗组对上述异常皆有不同程度的改善。结论　清开灵有不同程度的改善通气异常 ,纠正酸碱平衡紊乱的作用 Objective To observe the effect of Qingkailing injection on the changes of blood gas in rabbits with cerebral hematoma. Methods The intracerebral hematoma model of rabbit was duplicated by intracranial burial method with autologous blood clots. The changes of blood gas were measured at different time after the formation of cerebral hematoma. Results After the formation of cerebral hematoma, the animals had hyperventilation, manifested as a mixed acid-base balance disorder of metabolic acidosis and respiratory alkalosis, and Qingkailing treatment group had various degrees of improvement in these abnormalities. Conclusion Qingkailing can improve ventilatory abnormalities in different degrees and correct the effects of acid-base balance disorder