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(硫)脲、亲核活化基与辅助基构成的手性双功能(硫)脲催化剂,具有易于调控的结构和优异的催化性能,因而,双功能(硫)脲催化成为目前不对称有机催化的一个重要研究领域.各类活化基的引入显著影响了该类催化剂的催化性能,成为催化剂设计的主要考虑方向,获得了广泛关注.此外,合适辅助基的引入也可调控与优化催化性能,成为催化剂设计的一个重要补充方法.然而,到目前为止尚没有利用辅助基策略构建双功能(硫)脲催化剂的系统的综述.从非手性辅助基与手性辅助基角度综述了双功能(硫)脲催化剂的设计与构建以及这些催化剂在系列不对称有机催化研究中的应用,阐述了辅助基结构中的位阻、手性环境、电子效应、氢键给体等因素对催化性能的影响作用,并对其今后的发展进行了展望.
(Thiol) urea, a nucleophilic activating group and a helper, has an easily controlled structure and excellent catalytic performance. Therefore, the bifunctional (thiourea) urea has become a catalyst for the current asymmetric organic catalysis The introduction of various activated groups significantly affect the catalytic performance of these catalysts has become the catalyst design of the main considerations, has received widespread attention.In addition, the introduction of a suitable auxiliary group can also be controlled and optimized catalytic performance, However, to date, there is no systematic review on building a bifunctional (thiourea) catalyst using a co-base strategy.This review summarizes the applications of bifunctional (thiourea) catalysts from the perspective of achiral and chiral auxiliary groups Sulfur) urea catalyst design and application of these catalysts in a series of asymmetric organic catalysis, the effect of steric hindrance, chiral environment, electron effect, hydrogen bond donor and other factors on the catalytic performance It also gives a prospect of its future development.