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目的:研究氟西汀对非溃疡性消化不良(NUD)患者的精神心理状态、消化道症状及胃排空功能的影响。 方法:将44例有精神心理障碍的NUD患者随机分为两组,一组服用氟西汀,另一组服用莫沙必利治疗,疗程4wk。治疗前后分别对患者进行汉密尔顿抑郁量表(HAND)、汉密尔顿焦虑量表(HAMA)评分及消化道症状积分,并观察治疗前后胃排空功能变化。 结果:氟西汀组治疗后HAMD,HAMA评分均较治疗前显著降低,而莫沙必利组HAMD评分也有明显降低。两组治疗后的HAMD,HAMA评分均有显著性差异。两组患者治疗后的消化道症状积分均较治疗前显著降低,两药疗效比较无显著性差异。治疗后,两组患者胃排空均明显加速,以莫沙必利组更为显著。 结论:氟西汀可能既能作用于中枢神经系统,改善患者精神心理状态,从而增强其对躯体不适的耐受性,又能间接加速胃排空而发挥对NUD的治疗作用。
Objective: To study the effect of fluoxetine on mental state, gastrointestinal symptoms and gastric emptying in patients with non-ulcer dyspepsia (NUD). Methods: Forty-four patients with NUD who had mental disorders were randomly divided into two groups: one was fluoxetine, the other was mosapride. The course of treatment was 4 weeks. Before and after treatment, the Hamilton Depression Rating Scale (HAND), Hamilton Anxiety Scale (HAMA) score and gastrointestinal symptom scores were respectively observed, and the changes of gastric emptying function before and after treatment were observed. Results: The HAMD and HAMA score of fluoxetine group were significantly lower than those before treatment, while the HAMD score of mosapride group was significantly lower. After treatment, HAMD and HAMA scores of both groups were significantly different. Two groups of patients after treatment of gastrointestinal symptoms scores were significantly lower than before treatment, the two drugs showed no significant difference in efficacy. After treatment, gastric emptying was significantly accelerated in both groups, more significantly in the mosapride group. Conclusion: Fluoxetine may act on the central nervous system, improve the mental state of patients, thereby enhancing their tolerance to physical discomfort, but also indirectly accelerate the gastric emptying and play a therapeutic role in the NUD.