论文部分内容阅读
近十几年来,不对称电合成越来越受到重视。有关苯乙酮不对称电还原已有过不少报道。其中Kariv用奎尼丁作手性吸附诱导剂时,光学收率最高为14.5％。1984年,我们实验室曾以盐酸士的宁为手性吸附诱导剂对苯乙酮进行不对称电还原,光学收率为9.7％,又以四环素类抗菌素为手性吸附诱导剂,得到α-苯乙醇的光学收率为4.8～18.5％。本文研究了不同电解方式和通电量对α-苯乙醇光学收率与化学收率的影响。实验证明静态薄液层电解法优于Kariv的滴加搅拌法,前者可使α-苯乙醇的光学收率达21.8％。
In recent ten years, asymmetric synthesis has attracted more and more attention. There have been many reports about the asymmetric reduction of acetophenone. Among them, the highest optical yield of Kariv with quinidine as an inducer of chiral adsorption was 14.5%. In 1984, our laboratory had the asymmetric reduction of acetophenone with chlorambucil instead of chiral adsorption inducer, the optical yield was 9.7%, and the tetracycline antibiotic was used as chiral adsorption inducer to obtain α- The optical yield of phenethyl alcohol was 4.8 to 18.5%. In this paper, the effects of different electrolysis methods and electrification on the optical yield and chemical yield of α-phenylethanol were studied. Experiments show that static thin-layer electrolysis is better than Kariv’s dropping-stirring method, the former can make the optical yield of α-phenylethanol reach 21.8%.