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目的对某院抗肿瘤靶向药物阿帕替尼临床应用情况进行回顾性调查分析并评价。方法调取某院2015年4月~2016年3月使用阿帕替尼的病例,评价其用药合理性及安全性。结果 2015年4月~2016年3月使用阿帕替尼的患者84例,符合药品说明书适应证有15例(占15.48%),不良反应主要为消化系统、高血压、皮肤毒性反应及骨髓抑制。结论阿帕替尼在临床应用中存在超说明书适应证用药、用法用量不适宜,临床上应高度重视该药的合理使用,临床药师应以此为工作切入点,提高药物治疗的安全性和有效性,促进临床合理用药。
Objective To retrospectively analyze and evaluate the clinical application of apatinib, an anti-tumor target drug in a hospital. Methods A sample of patients receiving apatinib was recruited from April 2015 to March 2016 in a hospital to evaluate the rationality and safety of the drug. Results In April 2015 to March 2016, 84 patients were treated with apatinib, 15 patients (15.48%) were in compliance with the instruction manual of the drug, and the adverse reactions were mainly digestive system, hypertension, dermal toxicity and myelosuppression . Conclusion Apatinib in the clinical application of indications over the indications drug usage is not appropriate dosage, the clinical should attach great importance to the rational use of the drug, clinical pharmacists should use this as a starting point to improve the safety and effectiveness of drug treatment Sex, promote clinical rational use of medicine.