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目的探讨新疆喀什地区维吾尔族急性冠状动脉综合征(ACS)患者血清脑钠肽(BNP)及血浆同型半光氨酸(Hcy)与预后的相关性。方法选取2013年2月~2014年3月我院收治的维吾尔族ACS患者100例为研究对象,将其分为急性心肌梗死(AMI)组和不稳定型心绞痛(UA)组,各50例;并选取同期健康者50名为对照组。对比三组BNP和Hcy的检测结果,并分析与预后的关系。结果相较于对照组,AMI组和UA组的BNP、Hcy浓度显著上升,差异有统计学意义(P<0.05);AMI组入院时GRACE评分为(150.2±2.3)分,UA组为(120.2±1.9)分,对照组为(100.5±2.1)分,差异有统计学意义(P<0.05);分别在治疗后3、6、12个月时展开随访,AMI组死亡2例,UA组死亡1例,对照组无死亡事件发生。结论临床上通过检测血清BNP和血浆Hcy浓度,可对ACS的病情发展进行有效诊断,为治疗提供准确的参考依据,对保障预后,提高患者生存质量意义显著,值得临床广泛推广应用。
Objective To investigate the relationship between serum brain natriuretic peptide (BNP) and plasma homocysteine (Hcy) and prognosis in Uygur patients with acute coronary syndrome (ACS) in Kashgar region of Xinjiang. Methods A total of 100 Uighur ACS patients admitted to our hospital from February 2013 to March 2014 were enrolled in this study. The patients were divided into AMI group and unstable angina pectoris (UA) group, 50 cases in each group. 50 healthy people were selected as the control group. Comparison of three groups of BNP and Hcy test results, and analyze the relationship with the prognosis. Results Compared with the control group, the concentration of BNP and Hcy in AMI group and UA group increased significantly (P <0.05). The GRACE score in AMI group was (150.2 ± 2.3) at admission and was (120.2 ± 1.9) in the control group and (100.5 ± 2.1) in the control group, respectively (P <0.05). The patients were followed up at 3, 6 and 12 months after treatment. There were 2 deaths in the AMI group and 2 deaths in the UA group 1 case, no deaths occurred in the control group. Conclusions The serum BNP and plasma Hcy concentration can be used to diagnose the condition of ACS effectively and provide an accurate reference for the treatment. It is of great significance to guarantee the prognosis and improve the quality of life of patients, and it is worth widely clinical application.