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目的探讨survivin、P53蛋白在高发区食管癌中的表达及其相关关系。方法用免疫组化法对85例高发区食管癌组织及癌旁正常组织survivin和P53基因表达进行检测,分析survivin、P53与食管癌临床病理特点以及两者的相互关系。结果Survivin与P53蛋白在食管癌组织中的表达明显高于癌旁正常组织(P<0.01)。Survivin与患者的TNM分期和淋巴结转移与否有关(P<0.05),survivin与P53表达显著相关(P<0.05)。结论Survivin蛋白的表达与食管癌的临床分期和淋巴结转移有关,survivin与P53蛋白可作为食管癌检测的一个分子生物学指标。
Objective To investigate the expression of survivin and P53 protein in esophageal cancer of high incidence area and their correlation. Methods The expression of survivin and P53 in 85 cases of esophageal cancer tissues and adjacent normal tissues were detected by immunohistochemistry. The clinicopathological characteristics and the relationship between survivin, P53 and esophageal cancer were analyzed. Results The expression of Survivin and P53 protein in esophageal cancer tissues was significantly higher than that in adjacent normal tissues (P <0.01). Survivin was correlated with TNM stage and lymph node metastasis (P <0.05), and survivin was significantly correlated with P53 expression (P <0.05). Conclusion The expression of Survivin protein is correlated with the clinical stages and lymph node metastasis of esophageal carcinoma. Survivin and P53 protein may be used as a molecular biological marker in the detection of esophageal cancer.