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在裸小鼠体内移植了１４例肉瘤，成功５例（２例恶性纤维组织细胞瘤，２例横纹肌肉瘤，１例恶性外周细胞血管瘤），失败９例，接种成功率为３６％。分成移植成功群（ｓｕｃｃｅｅｄｅｄｉｎｔｒａｎｓｐｌａｎｔ，Ｓ群）和移植失败群（ｆａｉｌｅｄｔｏｔｒａｎｓｐｌａｎｔ，Ｆ群），对１４例被移植肉瘤的临床状况、组织病理学、免疫特性、ＤＮＡ含量、增殖因子和癌基因蛋白等进行了比较研究。Ｓ群中４例ＡＪＣ分期为Ⅲ或Ⅳ期，５例都是复发病例。Ｓ群的恶性程度明显高于Ｆ群，其中４例为高度恶性肉瘤，表现为细胞密度高，核异形性大，核分裂像显著增多。结果表明与肉瘤异种移植成功有关的某些可能因素为：组织来源，恶性程度高低，间质成份多寡，Ｓ期细胞百分数等。免疫学特性对肉瘤异种移植成功无明显影响。增殖因子Ｋｉ－６７和ＰＣＮＡ在Ｓ群中的表达明显高于Ｆ群，Ｓ群标本通常呈现较强的Ｋｉ－６７和ＰＣＮＡ染色，而Ｆ群通常显示较弱的染色，表明这两者是判定肉瘤生长速率和进展的较理想的指标。癌基因蛋白Ｐ５３在Ｓ群中的阳性表达率（６０％）明显高于下群（１８％）．进一步证明Ｐ５３在肿瘤进展中的重要作用。余癌某因蛋白在两群间的表达率无显著差别。
Fourteen cases of sarcoma were transplanted in nude mice, and 5 cases were successfully (2 cases of malignant fibrous histiocytoma, 2 cases of rhabdomyosarcoma, 1 case of malignant peripheral hemangioma), 9 cases failed, and the success rate of inoculation was 36%. Divided into successful transplanted groups (S group) and failed transplanted groups (F group), and performed the clinical conditions, histopathology, immune characteristics, DNA content, proliferation factors, and oncoproteins in 14 cases of transplanted sarcomas. compare research. In the S group, 4 cases of AJC were stage III or IV, and 5 cases were recurrent cases. The malignancy of the S group was significantly higher than that of the F group. Among them, 4 cases were highly malignant sarcoma with high cell density, large nuclear heterogeneity, and a significant increase in mitotic figures. The results showed that some possible factors related to the success of sarcoma xenografts were: tissue source, degree of malignancy, interstitial components, and percentage of cells in S phase. The immunological properties had no significant effect on the success of sarcoma xenografts. The expression of proliferation factor Ki-67 and PCNA in S group was significantly higher than that in F group. S group specimens usually showed strong staining of Ki-67 and PCNA, while F group usually showed weak staining, indicating that both were judgments. An ideal indicator of sarcoma growth rate and progression. The positive expression rate of oncogene protein P53 in group S (60%) was significantly higher than that of lower group (18%). Further proof of the important role of P53 in tumor progression. There was no significant difference in the expression rate of protein between the two groups due to the presence of protein in cancer.