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目的:探讨事件相关电位(ERP)在脑损害中的诊断价值。方法:用听觉oddball刺激序列ERP检测68例脑损害患者,其中脑梗塞34例,帕金森病18例,多发性硬化16例,并与51例年龄、性别和利手相匹配的正常人比较。结果:脑损害各组患者ERP的N2和P3波峰潜伏期(PL)较对照组显著延长(P<0.01),脑梗塞组和帕金森病组P3波幅较对照组显著降低(P<0.05)。结论:脑损害患者存在不同程度的认知功能障碍。
Objective: To investigate the diagnostic value of event-related potentials (ERP) in brain damage. Methods: Sixty-eight cases of brain damage were detected by auditory oddball stimulus sequence, including 34 cases of cerebral infarction, 18 cases of Parkinson’s disease and 16 cases of multiple sclerosis. The results were compared with those of 51 normal subjects matched by age, sex and hand. Results: The peak latency (ERP) of N2 and P3 in ERP group was significantly longer than that in control group (P <0.01). The amplitude of P3 in cerebral infarction group and Parkinson ’s disease group was significantly lower than that in control group (P <0.05). Conclusion: There are different degrees of cognitive dysfunction in patients with brain damage.