肿瘤坏死因子α(TNF-α)作为一种生物反应调节剂,不仅可以直接杀伤瘤细胞,而且可以干扰瘤组织的血供,致瘤组织坏死及瘤组织微循环pH值降低.而坏死及低pH值则可增加热疗对瘤组织的毒性.既往研究已表明,TNF可增强化疗药物的疗效,故探讨三者联合应用的价值是十分必要的,作者通过对TNF-α、卡铂或顺铂、热疗三种治疗方法的不同组合,观察其对小鼠移植瘤的抑制情况及血液毒性和胃毒性的比较,得出如下结论:①TNF-α可增加顺铂加热疗及卡铂加热疗的疗效(与对照组相比P<0.01);②TNF-α、卡铂或顺铂、热 Tumor necrosis factor-α (TNF-α), as a biological response modifier, can not only directly kill tumor cells, but also interfere with the blood supply of tumor tissues. The tumor tissue necrosis and the tumor tissue microcirculation pH value are reduced. Necrosis and low pH can increase the toxicity of hyperthermia to tumor tissue. Previous studies have shown that TNF can enhance the efficacy of chemotherapeutic drugs, so it is necessary to explore the value of the combination of the three, the authors through the TNF-α, carboplatin or Shun Different combinations of platinum and hyperthermia were used to observe the inhibition of hematopoietic tumor in mice and the comparison of hematologic toxicity and gastric toxicity. The following conclusions were drawn: 1 TNF-α can increase cisplatin hyperthermia and carboplatin plus Efficacy of hyperthermia (P<0.01 compared with control group); 2 TNF-α, carboplatin or cisplatin, heat