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作者报告一例胰岛α细胞癌,经用放射免疫测定法发现患者血液中促肾上腺皮质激素,高血糖素,胃泌素的含量均增高。患者有贫血,浮肿,肝脏不规则肿大及肌无力,葡萄糖耐量试验呈糖尿病曲线,低血钾,且血浆皮质醇含量增高。对皮质醇增多症用1,2双(3吡啶)二甲基1丙酮(metyrapone即Su4885)治疗后,血浆皮质醇含量明显下降,但血钾仍低且浮肿未见消退,作者认为是Su4885抑制肾上腺皮质中的11β羟化酶使皮质醇分泌减少,而11-去氧皮质醇及11-去氧皮质酮的分泌增多,因此对电解质的紊乱有增无减,加用氨基导眠能(Aminoglutethimide)治疗后,血钾恢复正常,出现明显利尿且浮肿显著减轻。
The authors report a case of pancreatic islet cell carcinoma of the pancreas. Radioimmunoassay showed that adrenocorticotropic hormone, glucagon, and gastrin levels increased in all patients. Patients with anemia, edema, irregular liver enlargement and muscle weakness, glucose tolerance test showed diabetes curve, hypokalemia, and plasma cortisol levels increased. Plasma cortisol levels were significantly decreased after treatment with 1,2-bis (3-pyridyl) dimethyl-1-acetone (metyrapone, Su4885), but serum potassium was still low and edema was not resolved as evidenced by Su 4885 inhibition 11β-hydroxylase in the adrenal cortical decreased secretion of cortisol, while the secretion of 11-deoxycortisol and 11-deoxycorticosterone increased, thus increasing the disorder of electrolytes, adding Aminoglutethimide ) After treatment, serum potassium returned to normal, with significant diuresis and edema significantly reduced.