烟雾吸入性肺损伤(SII)者易发生细菌性肺炎和ARDS,可能与烟雾导致肺泡吞噬细胞(AM)功能损害有关。作者给绵羊吸入烟雾,观察SII前后AM抗菌能力变化以及AM对中性粒细胞(PMN)凋亡的影响。 方法 绵羊(n=9)麻醉后,气管插管接呼吸机辅助呼吸。纤维支气管镜末端嵌顿于二级支气管,冲洗远端气道获取支气管肺泡灌洗液(BALF)。在发烟器中燃烧40g棉花球以产生烟雾,绵羊在128次呼吸中吸入 Bacterial pneumonia and ARDS are most likely to occur in patients with smoke-induced lung injury (SII), which may be related to smoke-induced dysfunction of alveolar phagocytes (AM). The authors inhaled smoke to sheep and observed the changes of AM antibacterial ability before and after SII and the effects of AM on neutrophil (PMN) apoptosis. Methods Sheep (n = 9) anesthesia, endotracheal intubation ventilator-assisted breathing. Fiberoptic bronchoscopy incarcerated in the second bronchus, distal airway irrigation for bronchoalveolar lavage fluid (BALF). Burning 40 g of cotton balls in a smoke generator to generate smoke, the sheep inhaled 128 breaths