脂质代谢紊乱是冠心病主要的,独立的危险因素。脂质代谢相关基因的突变会导致血浆脂质代谢紊乱。这些基因多态性通过不同的作用机制和协同作用共同影响着脂质代谢,对动脉粥样硬化及冠心病的发生和发展起着重要作用。本文就近年来主要的脂质代谢相关基因多态性与冠心病易感性关系的研究现状作一综述。 Lipid metabolism disorder is the main, independent risk factor for coronary heart disease. Mutations in genes associated with lipid metabolism can lead to disorders in plasma lipid metabolism. These genetic polymorphisms affect lipid metabolism through different mechanisms of action and synergy, and play an important role in the pathogenesis and development of atherosclerosis and coronary heart disease. This review summarizes the current status of the research on the relationship between major lipid metabolism related gene polymorphisms and susceptibility to coronary heart disease in recent years.