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近几年来，随着对肿瘤发病机理研究的不断深入，发现Ｃｙｓｔａｔｉｎ家族作为半胱氨酸蛋白酶的内源性抑制剂，与肿瘤的发生、发展、浸润和转移关系非常密切，有可能成为临床诊断和预后检测的分子指标。１Ｃｙｓｔａｔｉｎ家族的发现１９８３年ＡｎａｓｔａｓｉＡ等１采用
In recent years, with the deepening of research on the pathogenesis of tumors, it has been found that the Cystatin family as an endogenous inhibitor of cysteine protease is closely related to the occurrence, development, invasion and metastasis of tumors, and may become a clinical diagnosis. And molecular indicators of prognosis testing. 1 The discovery of the Cystatin family was adopted in 1983 by Anastasi A et al.