癌细胞可降解糖类,产生代谢性乳酸盐的速度比正常细胞快很多。这个现象是个警示,表明有癌症存在,同时也为癌症的新治疗方法提供了途径。美国卡内基研究所的Wolf Frommer与智利科学家小组合作,发明了一种可以实时检测单个细胞乳酸盐水平的分子传感器。在此之前,没有其他方法能够实时无创地检测单个细胞的乳酸盐水平。在过去10年中,Frommer实验室开创性地使用了Frster共振能量转换传感器(Frster resonance energy transfer,FRET),检测有单纯荧光颜色变化的单个细胞中糖的浓度和流量。这一方法彻底改变了对细胞代谢的研究。受到糖传感器的鼓舞,From- Cancer cells can degrade sugars and produce metabolic lactate much faster than normal cells. This phenomenon is a warning that there is cancer, but also provides a new way for the treatment of cancer. Wolf Frommer, of the Carnegie Institution of the United States, in collaboration with a group of Chilean scientists, invented a molecular sensor that detects the level of lactate in individual cells in real time. Until then, there was no other way to detect the lactate levels of individual cells in real time and non-invasively. For the past 10 years, Frommer Laboratories pioneered the Frster Resonance Energy Transfer (FRET), which detects the concentration and flow of sugar in a single cell with a simple change in fluorescence color. This method revolutionized the study of cellular metabolism. Inspired by the sugar sensor, From-