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探讨幽门螺杆菌(helicobacter pylori,Hp)感染与脑梗死发生的关系。本研究采集脑梗死患者(46例)清晨空腹静脉血,同时选择未患有脑梗死且年龄>60岁其他疾病患者(42例),分别测定两组人群血清中幽门螺杆菌特异性IgG、IgA、IgM抗体及脑梗死相关危险指标[C反应蛋白(CRP)、血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、血浆纤维蛋白原(FIB)],采用颈部血管彩色多普勒检查颈部血管的狭窄程度、斑块有无,并对两组患者血清中幽门螺杆菌特异性IgG、IgA、IgM抗体阳性率进行比较分析,分析Hp感染与颈部血管病变、脑梗死相关因子水平的关系。结果显示,病例组血清幽门螺杆菌IgG抗体、IgA抗体、IgM抗体阳性例数(阳性率)分别是37(80.43%)、27(58.70%)、12(26.09%),对照组血清幽门螺杆菌IgG抗体、IgA抗体、IgM抗体阳性例数(阳性率)分别是24(57.14%)、12(28.57%)、3(7.14%),且三种特异性抗体阳性率在病例组和对照组比较的结果差异有统计学意义(P<0.05)。IgG抗体阳性者颈动脉斑块及颈动脉狭窄的发生率均高于IgG抗体阴性者,两组比较差异有统计学意义(χ~2=18.011、4.023,均P<0.05)。IgG抗体阳性者CRP水平及血FIB水平明显高于IgG抗体阴性者,两组比较差异有统计学意义(t=3.482、3.433,均P<0.05)。人体幽门螺杆菌感染可能是促进脑梗死发生的危险因素之一,Hp感染可能诱导血管炎症发生,参与动脉斑块的形成,治疗脑梗死的同时应考虑Hp的感染、发生和治疗。
To investigate the relationship between Helicobacter pylori (Hp) infection and cerebral infarction. In this study, early fasting venous blood was collected from 46 patients with cerebral infarction and 42 other patients without cerebral infarction aged more than 60 years (42 patients) were collected. Serum Helicobacter pylori-specific IgG, IgA (CRP), serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL- C), fibrinogen (FIB)]. The degree of neck stenosis and plaque were examined by color Doppler of neck vessels. The Helicobacter pylori-specific IgG, IgA, IgM Antibody positive rate comparative analysis to analyze the relationship between Hp infection and cervical vascular disease, cerebral infarction related factors. The results showed that the positive cases (positive rate) of Helicobacter pylori IgG, IgA and IgM were 37 (80.43%), 27 (58.70%) and 12 (26.09%) respectively in the case group. The serum Helicobacter pylori The positive rates of IgG, IgA and IgM were 24 (57.14%), 12 (28.57%) and 3 (7.14%), respectively. The positive rate of the three specific antibodies in the case group and the control group The difference was statistically significant (P <0.05). The positive rates of carotid artery plaque and carotid artery stenosis were higher in IgG antibody positive patients than in IgG antibody negative patients. There was significant difference between the two groups (χ ~ 2 = 18.011, 4.023, all P <0.05). The levels of CRP and FIB in patients with positive IgG were significantly higher than those with negative IgG antibody (t = 3.482, 3.433, both P <0.05). Human Helicobacter pylori infection may be one of the risk factors to promote cerebral infarction. Hp infection may induce vascular inflammation and participate in the formation of arterial plaque. Hp infection, occurrence and treatment should be considered in the treatment of cerebral infarction.