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目的:研究补益肝肾中药对缺血性脑卒中模型大鼠造模后脑源性神经生长因子(BDNF)表达的影响,探讨补益肝肾中药修复神经系统损伤的作用机制。方法:采用老龄雌雄各半SD大鼠线栓法阻塞大脑中动脉,建立缺血性脑卒中的动物模型。观察补益肝肾中药对模型大鼠脑细胞BDNF表达的影响。结果:中药组在给药第7天后BDNF表达有明显差异(P<0.05),2周时达高峰。结论:补益肝肾中药能保护和改善缺血性脑卒中,对神经再生有促进作用。
Objective: To investigate the effect of tonifying liver, kidney and Chinese herbs on the expression of brain-derived nerve growth factor (BDNF) in rats with ischemic stroke model and to explore the mechanism of Chinese herbal medicine for replenishing liver and kidney to repair nervous system injury. Methods: The aged male and female SD rats were subjected to occlusion of the middle cerebral artery by thread occlusion method to establish an animal model of ischemic stroke. To observe the effect of tonifying liver and kidney medicine on the expression of BDNF in brain cells of model rats. Results: The expression of BDNF in Chinese herbal medicine group after 7 days of administration was significantly different (P <0.05), reaching the peak at 2 weeks. Conclusion: Tonic liver and kidney Chinese medicine can protect and improve ischemic stroke, promote nerve regeneration.