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目的:考察不同质量分数的丁香挥发油对磷酸川芎嗪贴剂的经皮促渗作用。方法:用改良Franz扩散池法,以氮酮为阳性对照,不含促渗剂的磷酸川芎嗪贴剂为阴性对照,考察含3%,5%,7%,10%的丁香挥发油对模型药磷酸川芎嗪经小鼠皮肤的促渗效果,采用HPLC测定磷酸川芎嗪的含量。结果:4种质量分数的丁香油对磷酸川芎嗪12 h平均累积渗透量(Q12)分别为3.030,4.066,1.845,1.205 mg.cm-2;其12 h时增渗倍数分别为1.54,2.06,0.96,0.62。与阴性对照组的Q12比较,5%丁香油与3%丁香油促渗作用显著。结论:3%,5%的丁香油能明显提高磷酸川芎嗪在贴剂中的渗透量,且促渗效果好。
Objective: To investigate the transdermal effect of ligustrazine phosphate patch with different mass fraction of clove volatile oil. Methods: A modified Franz diffusion cell method was used to test the effects of the essential oil containing clozaprine (3%, 5%, 7% and 10%) on the model drug Ligustrazine phosphate by the skin of mice to promote penetration, the determination of ligustrazine phosphate content. Results: The average cumulative permeation amount (Q12) of four kinds of clove oil and ligustrazine phosphate 12h were 3.030, 4.066, 1.845 and 1.205 mg.cm-2 respectively at 12 h, and their multiplication rates at 12 h were 1.54, 2.06, 0.96, 0.62. Compared with the Q12 of the negative control group, the effect of 5% clove oil and 3% clove oil is obvious. Conclusion: 3%, 5% clove oil can significantly improve the penetration of tetramethylpyrazine phosphate in the patch, and the penetration effect is good.