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目的:对五加科五加属植物无梗五加Acanthopanax sessiliflorus果的化学成分进行分离与鉴定。方法:采用硅胶柱色谱,Sephadex LH-20柱色谱等方法对化学成分进行分离及纯化,根据化合物理化性质及波谱数据鉴定其结构。结果:分离得到9个化合物,oleanolic acid-3-O-6′-O-methyl-β-D-glucuronopyranoside(1),22-α-hydroxychiisanogenin(2),齐墩果酸-3-O-β-D-葡萄糖醛酸苷(momordin Ib3),齐墩果酸-3-O-β-D-葡萄糖苷(oleanolic acid-3-O-β-D-glucopyranoside4),齐墩果酸(oleanolicacid5),chiisanogenin(6),(-)-芝麻脂素[(-)-sesamin7],胡萝卜苷(daucosterol8),β-谷甾醇(β-sitosterol9)。结论:化合物1是首次从五加属植物中分离得到,化合物2~5是首次从该植物中分离得到。
OBJECTIVE: To isolate and identify the chemical constituents of the Acanthopanax sessiliflorus fruit from the genus Wuda. Methods: The constituents were isolated and purified by silica gel column chromatography and Sephadex LH-20 column chromatography. Their structures were identified by physicochemical properties and spectral data. Results: Nine compounds were isolated and identified as oleanolic acid-3-O-6’-O-methyl-β-D-glucuronopyranoside (1), 22-α-hydroxychiisanogenin Momordin Ib3, oleanolic acid-3-O-β-D-glucopyranoside 4, oleanolic acid 5, (-) - sesamin [(-) - sesamin7], daucosterol8, and β-sitosterol9. Conclusion: Compound 1 was isolated from Caecum for the first time. Compounds 2 ~ 5 were isolated from this plant for the first time.