论文部分内容阅读
目的 观察α 2b干扰素联合苦参碱治疗慢性乙型病毒性肝炎的临床疗效及对乙肝病毒标志物的影响。方法 选择深圳市东湖医院 1998- 0 8～ 2 0 0 4 - 0 2门诊及住院的慢性乙型肝炎患者 4 6 0例 ,随机分成治疗组2 95例 ,给予 10 %葡萄糖 2 5 0mL +苦参碱 15 0mg每日 1次静滴 (3个月 ) ,给予α 2b干扰素 5 0 0万单位 ,每日 1次肌肉注射 (10d) ,以后为隔日 1次 (6个月 )。对照组 16 5例 ,单用α 2b干扰素治疗 ,剂量疗程与治疗组相同。两组同时给予 10 %葡萄糖 15 0mL +强力宁 10 0mL每日 1次静脉滴注 3个月。同时观察两组患者的肝功能 ,乙肝病毒标志物的变化。结果 两组患者血清ALT及AST在治疗过程的复常率差异无显著性 (P >0 0 5 ) ,HbeAg阴转率分别是 5 7 0 %和 38 8% (P <0 0 1) ,HBVDNA阴转率是 5 9 3%和 4 2 4 % (P <0 0 1) ,抗Hbe阳转率是5 0 8%和 33 9% (P <0 0 1)。结论 α 2b干扰素联合苦参碱是治疗慢性乙型病毒性肝炎较有效的方法。
Objective To observe the clinical efficacy of α 2b interferon combined with matrine in the treatment of chronic viral hepatitis B and its effect on hepatitis B virus markers. Methods A total of 460 cholestatic hepatitis B patients from 1998 to 2008-2010 in Shenzhen East Lake Hospital were randomly divided into treatment group (955 cases), treatment group (250 cases) with 10% glucose and matrine A base 15 0 mg once daily intravenous infusion (3 months), giving α 2b interferon 500 million units, once daily intramuscular injection (10d), followed by every other day (6 months). The control group of 16 5 cases, with α 2b interferon therapy alone, the same dose of treatment and treatment group. Both groups were given 10% glucose 15 0mL + strong Ning 10 0mL daily intravenous infusion of 3 months. At the same time, two groups of patients were observed for liver function, hepatitis B virus markers changes. Results There was no significant difference in the normalization rate of serum ALT and AST between the two groups (P> 0.05), and the negative conversion rates of HbeAg were 57.0% and 38.8% (P <0.01) respectively. HBVDNA The negative conversion rates were 593% and 42.4%, respectively (P <0.01). The anti-HBe conversion rates were 58.0% and 33.9%, respectively (P <0.01). Conclusions α 2b interferon combined with matrine is an effective treatment for chronic hepatitis B virus.