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Objective To study single wall carbtion nanotubes (SWCNT) and its role in inducing inflammatory cytokines in the cruor-fibrinolysis system of rat. Methods Twenty tione Wistar rats were divided into four groups: 1) ctiontrol;2) low-dose SWCNT (0.15 mg/kg BW);3) medium-dose SWCNT (0.75 mg/kg BW);4) high-dose SWCNT (1.5 mg/kg BW). Intratracheal instillatition of SWCNT suspensitions was administered to rats tionce per day for 21 days. In order to assess the exposure effect of SWCNT to the rats, activity of Inflammatory cytokine was measured and markers of cruor-fibrinolysis system were studied via ELSIA. Also, change in clotting time was recorded and histopathology was studied. Results IL-6 and IL-8 ctioncentratitions of rats exposed to SWCNT were significantly higher than those in ctiontrols (P