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1992～1995年,我们收治8例高热惊厥(单纯型)患儿(年龄2～5岁),均用异丙嗪1～2mg/(kg·次)肌注止痉,用后抽搐停止,体温下降,但半小时内出现寒战、惊恐哭闹各3例,2例于数分钟后再次抽搐,症状复现。给予物理降温、吸氧、鲁米那钠5～8mg/(kg·次)肌注或安定0.1～0.3mg/(kg·次)稀释静注,上述症状迅速消失。继续治疗原发病,惊厥未再发作。 讨论:异丙嗪为组胺H_1受体拮抗剂,通过竞争性阻断组胺H_1受体而产生抗组胺作用,其较易进入脑组织,有明显的镇静作用,但同时亦可引发失眠、昏迷、惊厥等中枢神经兴奋症状及震颤等锥体外系
From 1992 to 1995, we treated 8 children (aged 2 to 5 years old) with febrile seizures (simple type). All of them were treated with promethazine 1 ~ 2mg / (kg ·) Fell, but within half an hour there chills, frightened crying in 3 cases, 2 cases again in a few minutes after convulsions, symptoms recurrence. Give physical cooling, oxygen, luminal sodium 5 ~ 8mg / (kg · times) intramuscular or stable 0.1 ~ 0.3mg / (kg · times) diluted intravenous infusion, the symptoms disappear rapidly. Continue to treat the primary disease, convulsions did not attack. Discussion: Promethazine is a histamine H 1 receptor antagonist that produces anti-histamine effects by competitively blocking histamine H 1 receptors, which is more likely to enter the brain and has a pronounced sedative effect, but also induces insomnia , Coma, convulsions and other central nervous excitement symptoms and tremor and other extrapyramidal system