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对于DNA去甲基化的研究以往都是以DNA甲基转移酶(DNA methyltransferase,DNMT)为靶向分子,通过抑制DNMT来恢复抑癌基因的功能,从而达到治疗肿瘤的目的。去甲基化药物就是通过抑制DNMT的活性使复制后的DNA不能
For the demethylation of DNA, DNA methyltransferase (DNMT) has been used as a target molecule to restrain the function of tumor suppressor gene by inhibiting DNMT so as to achieve the purpose of treating tumors. Demethylating agents disable replication of DNA by inhibiting DNMT activity