用电喷雾正交飞行时间质谱仪分别研究了以α 环糊精、β 环糊精和γ 环糊精作为手性拆分剂对手性药物伪麻黄碱的分子识别效应 ,同时还分别研究了Nozzle电压的变化对α 环糊精、β 环糊精和γ 环糊精的手性识别的影响 .在质谱图中能明显反映出三种手性拆分剂都具备很强的手性识别能力 ,随Nozzle电压的改变 ,三种手性拆分剂又分别具有各自的手性识别特征 The molecular recognition effect of chiral drug pseudoephedrine using α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin as chiral resolving agents was studied by using electrospray ionization time-of-flight mass spectrometer. The effects of Nozzle voltage The effect of changes on the chiral recognition of α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin clearly shows that the three chiral resolving agents all have strong chiral recognition ability, Voltage changes, the three chiral resolving agents, respectively, have their own chiral recognition characteristics