论文部分内容阅读
马蔺子是中草药马蔺(Iris pallasii Fischar.)的干燥成熟种子。经瘤谱筛选从马蔺子中提得一种抗癌有效成分马蔺子甲素(以下简称甲素),结构为6-甲氧基-2-△~(10′)顺十七烯-1,4-苯醌。临床试用表明,对急性白血病和实体癌均有一定疗效。甲素腹腔注射3～7 mg/kg,对小鼠肿瘤 U_(14)抑制率为40～55.5%;淋巴肉瘤3 mg/kg,抑制率33.3%;肝癌实体7 mg/kg,抑制率38%;肝癌腹水5 mg/kg,生命延长率158%;艾氏腹水5 mg/kg,生命延长率83%。口服180 mg/kg,对 U_(14)抑
Mazizi is a dry mature seed of Iris pallasii Fischar. An anti-cancer active ingredient madolin (hereinafter abbreviated as A) was extracted from Malus urticae by the method of tumor profile screening. The structure was 6-methoxy-2-△ (10′) cis-hexadecene-1, 4- Benzoquinone. Clinical trials have shown that it has a certain effect on acute leukemia and solid cancer. Intraperitoneal injection of A (3-7 mg/kg) inhibited the tumor U_(14) by 40~55.5%; lymphosarcoma 3 mg/kg, inhibition rate 33.3%; liver solid 7 mg/kg, inhibition rate 38% Liver cancer ascites 5 mg/kg, life extension rate 158%; Ehrlich ascites 5 mg/kg, life extension rate 83%. Oral 180 mg/kg, inhibiting U_(14)