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由于细胞生活环境的变化或物理、化学等因素的刺激,一种已经分化成熟的组织,在形态和机能上变为另一种组织的过程,在病理学上称为化生。胃肠腺化生是一种较为常见的化生现象,又称为肠上皮化生,简称肠化。这是指在炎症、自身免疫、肠内容物持续反流等因素的作用下,胃粘膜上皮及固有腺体(主要是幽门腺)逐渐变化成近似于肠腺上皮组织的病理过程。在显微镜下,可以见到原有的胃粘膜上皮萎缩消失,代之以类似小肠粘膜的组织,包括:高柱状、有刷状缘、具备吸收功能的吸收细胞;充满大量粘液的杯状细胞;短柱状、含嗜酸颗粒的潘氏(Paneth)细胞。吸收细胞数量最多,
Due to changes in the cell’s living environment or stimuli of physical and chemical factors, a well-differentiated and mature tissue changes its form and function into another tissue process, which is called metaplasia in pathology. Gastrointestinal gland metaplasia is a relatively common metaplasia, also known as intestinal metaplasia, referred to as intestinal metaplasia. This refers to the pathological process in which gastric epithelium and intrinsic glands (mainly pyloric glands) are gradually changed to resemble intestinal epithelial tissues under the influence of inflammation, autoimmunity, and continuous reflux of intestinal contents. Under the microscope, it can be seen that the original gastric epithelial atrophy disappeared and replaced by a tissue similar to the small intestine mucosa, including: high columnar, brush-like margin, absorptive cells with absorption function; goblet cells filled with large amounts of mucus; Short columnar Paneth cells containing eosinophilic particles. Absorb most cells,