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乙肝疫苗自列入计划免疫管理后,新生儿乙肝疫苗接种逐步走上正轨,对控制我国乙肝的流行起到了积极有效的作用。为了解乙肝疫苗接种后抗体维持时间及加强免疫效果,我们于1996年9—11月在建德市新安江镇进行了乙肝疫苗初免后5年抗体水平及加强接种效果观察,现将结果报告如下。材料与方法1.观察对象:选择建德市新安江镇城镇居民1991年出生的、接种卡、证齐全。按规定完成乙肝疫苗全部基础免疫的儿童为观察对象。2.疫苗及接种方法:基础免疫使用上海生物制品研究所生产的血源疫苗,按0、1、6、免疫程序,接种剂量为首针30ug,第二、三针为10ug。本次加强接种使用深圳康泰公司生产的乙肝基因疫苗(批号为2960401-2),注射剂量为5微克(0.5ml)。初免及加强免疫均为上臂三角肌肌肉注射。3.实验室检查:(1)采血:于加强接种前和免后6周各采静脉血2毫升。(2)抗-HBs、抗-HBc、HBsAg测定:用SPRIA法测抗-HBs,放免抗-HBs诊断盒(批号96111210)由
Hepatitis B vaccine since included in the planned immunization management, neonatal hepatitis B vaccination gradually on the right track on the control of the epidemic of hepatitis B has played a positive and effective role. In order to understand the antibody maintenance time after hepatitis B vaccination and to enhance the immune effect, we conducted an antibody titer and enhanced vaccination effect at 5 years after the hepatitis B vaccine was first vaccinated in Xin’anjiang Town, Jiande City from September to November, 1996. The results are reported as follows. Materials and methods 1.Objective: Select Jian’an Xin’anjiang town residents born in 1991, vaccination card, card complete. According to the provisions of hepatitis B vaccine to complete the basic immunization of children as the observation object. 2. Vaccination and vaccination methods: The basic immunization using Shanghai Institute of Biological Products produced by blood-borne vaccine, 0,1,6, immunization program, the first dose of 30ug dose, the second and third needles for the 10ug. The hepatitis C vaccines produced by Shenzhen Kangtai Co., Ltd. (batch No. 2960401-2) were boosted at a dose of 5 micrograms (0.5 ml). Primaries and enhance immunity are upper arm deltoid muscle injection. 3. Laboratory tests: (1) blood collection: to strengthen the pre-vaccination and 6 weeks after taking venous blood 2 ml. (2) anti-HBs, anti-HBc, HBsAg determination: anti-HBs by SPRIA assay, anti-HBs diagnostic cassette (batch number 96111210) from