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1924年道勃罗优耳斯基用泉水喂实验鼠,什哈罗夫用患区河水喂家兔做试验,1924-25年,什帕巧夫用患区河水喂家兔,均未能复制成乌洛夫病,谢尔盖也夫斯基提出镰刀菌为大骨节病的致病因子系当地粮食被真菌感染以后产生毒性所致,此后汝拉夫廖夫,鲁宾斯坦因进行了详尽的研究,1948年后用1238号FusariumSporotrichiella varo poae毒性菌株制成10%生理鹽水菌粮溶液,用导管灌入大白鼠,实验大白鼠发生骨营养不良的病理过程,X线可见干骺早期癒合,骨质疏松,干骺骨骺线变化(干骺骨骺线弯曲,模糊不清,骨骺干骺间没有
In 1924, Dabrookowski used spring water to feed rats, and Shkarov used rabbits in the affected area to feed rabbits. In 1924-25, Shpachov used rabbits in the affected area to feed rabbits and failed to replicate Into Ulov disease, Sergeyevskis proposed fusarium is the causal factor for Kashin-Beck disease caused by fungal local food caused by toxicity, since then Ru Lovliv, Rubinstein conducted a detailed Study, after 1948 with 1238 FusariumSporotrichiella varo poae toxicity strains made of 10% saline solution, the catheter into the rats, the experimental rat bone malnutrition pathological process, early visible metaphyseal healing of X-ray, bone Quality loose, epiphyseal epiphyseal line changes (epiphyseal epiphyseal line bending, blurred, there is no epiphyseal metaphyseal