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目的 :为了比较在不同介入因子影响下 ,SPECT所测犬的梗塞心肌和存活心肌。方法 :选择 12只杂种犬建立心梗模型 ,2 4h后给予 1.0mg硝酸甘油介入后行SPECT心肌灌注显像测出心梗面积。第三日将犬随机分为两组 :一组给予潘生丁介入后显像 ,另一组在常规静息状态下显像 ,分别求出心梗面积 ,显像结束后处死动物 ,采用与SPECT相似的方法 ,获得坏死心肌占左室心肌的百分比。结果 :病理性心梗面积为 17.80 %±3.0 7% ,硝酸甘油介入 ,静态状态下 ,潘生丁介入时SPECT心梗面积分别为 :19.98%± 3.16 %、2 5 .5 3%±3.91%、31.82 %± 2 .81%。硝酸甘油介入所测心梗面积最接近病理性心梗面积 (P >0 .0 5 )。静态状态下 ,潘生丁介入显像与硝酸甘油介入显像相比较后时心梗面积中有 2 1.5 2 %± 4 .8%、37.80 %± 4 .5 %的部份被认定是缺血尚存活心肌。结论 :利用硝酸甘油介入显像可以改善静息状态下及潘生丁介入的SPECT显像估测心梗面积的误差 ,提高缺血存活心肌检出率。
OBJECTIVE: To compare infarct and viable myocardium measured by SPECT in dogs under the influence of different interventional factors. Methods: 12 mongrel dogs were selected to establish the myocardial infarction model. After 24 h, 1.0 mg of nitroglycerin was injected into SPECT myocardial perfusion imaging to measure the myocardial infarct size. The third day dogs were randomly divided into two groups: one group given dipyridamole interventional imaging, the other group in the conventional resting state of imaging, respectively, to find the myocardial infarction area, imaging after the sacrifice of animals, with SPECT similar Method to obtain the percentage of necrotic myocardium in left ventricular myocardium. Results: The area of pathological myocardial infarction was 17.80% ± 3.07%. When nitroglycerin was involved, the area of SPECT myocardial infarction at the time of dipyridamole intervention were 19.98% ± 3.16%, 25.3% ± 3.91%, 31.82 % ± 2 .81%. The area of myocardial infarction measured by nitroglycerin intervention was the closest to the area of pathological myocardial infarction (P> 0.05). Static state, Interventional imaging of dipyridamole and nitroglycerin interventional imaging when compared with myocardial infarction area, 1.52% ± 4.8%, 37.80% ± 4.5% of the part was identified as ischemic survivors Myocardium. Conclusion: The use of nitroglycerin interventional imaging can improve the resting state and dipyridamole interventional SPECT imaging to assess the error of myocardial infarction area, improve the detection rate of myocardial infarction.