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对氯乙烯接触水平为213.21mg/m~3的31名工人和32名对照者进行了检查,表明FEP和Hb均值存在明显差异(P均小于0.01)。将实验组分为肝大组和非肝大组进行比较,肝大组的δ-ALA-μ、CP-μ和FEP均值明显高于非肝大组(P均小于0.05)。肝大组CP—μ超过正常值上限的百分率比非肝大组高(P小于0.005)。接触氯乙烯的工人在肝脏肿大的同时往往可检出卟啉水平的升高,调查结果提示:接触氯乙烯工人卟啉和卟啉前体的测定有可能成为发现早期毒作用损伤的健康监护指标。
Thirty-one workers and 32 controls who had exposure levels of 213.21 mg / m3 were examined, indicating a significant difference in mean FEP and Hb values (P <0.01). The experimental group was divided into two groups: the large liver group and the non-liver group. The mean δ-ALA-μ, CP-μ and FEP in the liver group were significantly higher than those in the non-liver group (P <0.05). The percentage of CP-μ exceeding the upper limit of normal in the large hepatic group was higher than that in the non-hepatic group (P less than 0.005). Workers exposed to vinyl chloride can often detect elevated levels of porphyrins when swollen in the liver. The findings suggest that the determination of porphyrin and porphyrin precursors exposed to vinyl chloride workers may be a health check for early detection of toxic effects index.