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目的:探讨中性粒细胞弹性蛋白酶(neutrophil elastase,NE)在Ⅲ型前列腺炎诊断中的意义。方法:ⅢA型36例与ⅢB型87例分别进行前列腺按摩液(expressed prostatic secretion,EPS)细菌培养、EPS常规检查、NIH-前列腺炎症状评分(NIH-CPSINE)、NE浓度的测定,然后行独立样本t检验和简单相关分析。正常对照组84例同样进行上述检查后分别与ⅢA型和ⅢB型进行独立样本t检验。结果:①ⅢA型和ⅢB型患者EPS中NE(t=6.32,P<0.05)差异有统计学意义,NE与白细胞呈现明显的正相关关系(r=0.878,P<0.05),两者CPSI(t=1.85,P>0.05)比较差异无统计学意义。②ⅢA型和对照组患者EPS中白细胞(t=13.74,P<0.05)、NE(t=6.499,P<0.05)、CPSI(t=23.76,P<0.05)差异有统计学意义。ⅢB型和对照组患者EPS中NE(t=2.14,P<0.05)、CPSI(t=33.15,P<0.05)差异有统计学意义,白细胞(t=1.49,P>0.05)无统计学意义。结论:NE在Ⅲ型前列腺炎的诊断中能够作为一个很有意义的指标,而NE浓度与白细胞呈较强的正比关系,提示NE浓度的高低能够反映出慢性前列腺炎的严重程度。
Objective: To investigate the significance of neutrophil elastase (NE) in the diagnosis of type Ⅲ prostatitis. Methods: 36 cases of type ⅢA and 87 cases of type ⅢB were subjected to bacterial culture of EPS, EPS routine examination, NIH-CPSINE and NE concentration respectively, Sample t test and simple correlation analysis. The normal control group of 84 patients also carried out the above tests, respectively, and Ⅲ A and Ⅲ B type independent sample t test. Results: ① There was a significant positive correlation between NE (t = 6.32, P <0.05) and NE and leukocyte in typeⅢA and type ⅢB patients (r = 0.878, P <0.05) = 1.85, P> 0.05) there was no significant difference between the two groups. ② The levels of leukocytes (t = 13.74, P <0.05), NE (t = 6.499, P <0.05) and CPSI (t = 23.76, P <0.05) in EPS of typeⅢA and control patients were statistically significant. There were significant differences in EPS between NE (t = 2.14, P <0.05) and CPSI (t = 33.15, P <0.05) in type ⅢB and control group. There was no significant difference between leukocytes (t = 1.49, P> 0.05) Conclusion: NE can be used as a meaningful indicator in the diagnosis of type Ⅲ prostatitis. However, NE concentration shows a strong positive correlation with leukocyte count, suggesting that the severity of chronic prostatitis can be reflected by the level of NE concentration.