目的正确、科学地评估胰岛 B 细胞功能、胰岛素抵抗度,是评价治疗NIDDM新药疗效及毒副作用的基础。结果论证了OGTT试验按kg体重、计算服糖总量和采用变化度描述负荷试验相关指标的合理性,科学性。结论糖负荷后2h,3h 血糖水平,可作为评估胰岛素抵抗度的定量指标;胰岛素,C 肽峰值,次峰值所处的时点及其浓度,可作为评估胰岛B细胞负荷度,胰岛素合成速度的定量指标。(Gt)/(Go)·(It)/(Io)·(Co)/(Ct)可用于胰岛素抵抗的判别。 Objective To evaluate the function and insulin resistance of islet B cells correctly and scientifically, which is the basis to evaluate the curative effect and side effect of new drug of NIDDM. The results demonstrate that the OGTT test based on kg body weight, calculate the total amount of sugar and the use of degree of variability to describe the load test related indicators of rationality and scientific. Conclusions The blood glucose level at 2h and 3h after glucose loading can be used as a quantitative index to evaluate insulin resistance. The peak value of insulin, C-peptide, the time point of secondary peak and its concentration can be used to evaluate the islet B cell load and insulin synthesis rate Quantitative indicators. Gt / Go / Ito / Ct can be used for the discrimination of insulin resistance.