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目的:探讨中国人群中DNA修复基因X线修复交叉互补因子3(X-ray cross-complementing group 3,XRCC3)241位点(XRCC3 Thr241Met)的基因多态性与肝细胞癌(hepatocellular carcinoma,HCC)遗传易感性的关联关系。方法:利用PubMed、EMBASE、万方数据库、中国期刊全文数据库及维普数据库检索国内外公开发表的关于XRCC3 Thr241Met的多态性与HCC关系的所有文献。采用Meta分析的方法合并所有纳入研究的优势比(odds ratios,ORs)值及其95%可信区间(confidence intervals,CIs)。根据人群分布地区及HBV慢性感染、吸烟暴露因素的不同进行亚组分析,并分析组间异质性的可能来源。结果:本文共纳入从2008~2012年发表的随机对照研究5篇,共计HCC患者1 741例,对照2 596例。①在中国人群中,XRCC3 Thr241Met的T等位基因及变异基因型与HCC的发生存在明显的相关性(OR T vs C=1.84,95%CI:1.19~2.85,POR=0.003;ORTT vs CC=4.71,95%CI:2.14~10.34,POR<0.001;ORCT vs CC.=1.59,95%CI:1.07~2.36,POR=0.022;ORTT vs CC+CT=4.21,95%CI:2.21~8.00,POR<0.001;ORCT+TT vs CC=1.83,95%CI:1.11~3.00,POR=0.017);②在广西人群中,携带XRCC3 Thr241Met的变异等位基因及基因型的个体,其HCC的易感性明显升高(OR T vs C=2.23,95%CI:1.32~3.77,POR=0.003;ORTT vs CC=5.74,95%CI:2.33~14.14,POR<0.001;ORCT vs CC=1.91,95%CI:1.23~2.99,POR=0.004;ORTT vs CC+CT=4.63,95%CI:2.20~9.76,POR<0.001;ORCT+TT vs CC=2.29,95%CI:1.26~4.18,POR=0.007);③未发现XRCC3 Thr241Met的基因多态性与HCC发病的2种危险因素HBV慢性感染、吸烟之间存在交互作用。结论:在中国人群尤其是广西人群中,XRCC3 Thr241Met的基因多态性与HCC的发病风险有关,但不存在基因与环境的交互作用。
Objective: To investigate the relationship between polymorphism of XRCC3 Thr241Met and hepatocellular carcinoma (HCC) in Chinese population of X-ray cross-complementing group 3 (XRCC3) Genetic susceptibility of the relationship. Methods: PubMed, EMBASE, Wanfang database, Chinese periodical full text database and VIP database were searched for all the published literature about the relationship between Thr241 Met polymorphism of XRCC3 and HCC at home and abroad. All odds ratios (ORs) and 95% confidence intervals (CIs) were included in the Meta-analysis. According to the population distribution area and chronic HBV infection, smoking exposure factors for subgroup analysis, and analysis of possible sources of heterogeneity between groups. Results: A total of 5 randomized controlled trials published from 2008 to 2012 were included in this study. A total of 1 741 HCC patients and 2 596 controls were included. ① In Chinese population, T allele and variant genotype of Thr241 Met in XRCC3 were significantly associated with the occurrence of HCC (OR T vs C = 1.84, 95% CI: 1.19-2.85, POR = 0.003; ORTT vs CC = 4.71, 95% CI: 2.14 to 10.34, POR <0.001 ORCT vs CC. = 1.59, 95% CI: 1.07-2.66, POR = 0.022 ORTT vs CC + CT = 4.21, 95% CI: 2.21-8.00 POR <0.001; ORCT + TT vs CC = 1.83, 95% CI: 1.11-3.00, POR = 0.017); ②The susceptibility to HCC in Guangxi population was significantly higher than that in individuals carrying XRCC3 Thr241Met variant allele and genotype (OR T vs C = 2.23, 95% CI: 1.32-3.77, POR = 0.003; ORTT vs CC = 5.74, 95% CI: 2.33-14.14, POR <0.001; ORCT vs CC = 1.91, 95% CI: POR = 0.004; POR = 0.004; ORTT vs. CC + CT = 4.63, 95% CI: 2.20-9.76, POR <0.001; ORCT + TT vs CC = 2.29, 95% CI: 1.26-4.18; There was no interaction between the gene polymorphism of Thr241Met in XRCC3 and the two risk factors of HCC, including chronic HBV infection and smoking. Conclusion: In Chinese population, especially Guangxi population, the gene polymorphism of Thr241Met in XRCC3 is associated with the risk of HCC, but there is no interaction between gene and environment.