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盐酸甲氟喹(Mefloquine hydrochloride,WR 142490)即2,8-双(三氟甲基)-α-(2-哌啶基)-4-喹啉甲醇盐酸盐,经最近研究证明对一株抗氯喹和抗乙胺嘧啶的恶性疟原虫有长效抑制作用。本文报道了此药的进一步研究结果。 17例无免疫力男性成人受试者,分成5个组,每组中1或2例给服WR 142490单剂量1克,另1或2例则不给药以作对照。在给药后的2～21天内,全部受试者接受感染抗性恶性疟原虫越南(Marks)株的斯氏按蚊叮咬,然后个别采血涂成厚血膜镜检。血检至少
Mefloquine hydrochloride (WR 142490), 2,8-bis (trifluoromethyl) -α- (2-piperidinyl) -4-quinolinemethanol hydrochloride, Long-term inhibition of Plasmodium falciparum resistant to chloroquine and pyrimethamine. This article reports the results of further study of this drug. Seventeen non-immunocompetent male adult subjects were divided into five groups, one or two in each group were given a single dose of WR 142490 1 gram, and the other one or two were not administered as controls. Within 2 to 21 days after dosing, all subjects received An. & Quot; An. & Quot; An. & Lt; RTI ID = 0.0 & gt; An. & Lt; / RTI & gt; Anopheles mosquitoes infected with the resistant strain of Plasmodium falciparum in Vietnam and were then smear-collected for thick film microscopy. Blood tests at least