论文部分内容阅读
目的:观察自拟乳积方防治乳腺癌患者术后复发转移的临床疗效。方法:回顾性分析109例手术后的乳腺癌患者,根据服药情况分为治疗组(乳积方配合西药组)57例和对照组(西药组)52例,观察患者的总生存率(OS)、无疾病生存率(DFS)、生存质量情况。结果:2组患者在年龄、月经状况、病理类型、临床分期、淋巴结转移情况、激素受体表达情况、Her-2表达情况等基线资料方面,具备方差齐性,差异无统计学意义(P<0.05)。随访时间13～126月,中位随访时间61月;2组3年DFS率分别为91.4%和68.4%,差异有统计学意义(P<0.01);3年OS率分别为100.0%和97.1%,差异无统计学意义(P>0.05);5年DFS率分别为63.6%和36.8%,差异有统计学意义(P<0.01)。5年OS率分别为93.5%和62.5%,差异有统计学意义(P<0.01);采用乳腺癌患者生存质量评分系统(FACT-B)对患者生存质量进行评分,治疗组治疗后各项功能较治疗前有明显改善,差异有统计学意义(P<0.01);对照组部分功能较治疗前有明显改善,差异有统计学意义(P<0.01);治疗后2组各项功能评分比较,差异有统计学意义(P<0.01)。结论:乳积方配合西药治疗乳腺癌术后患者,可进一步延长患者总生存及无疾病生存时间,改善患者生存质量。
Objective: To observe the clinical efficacy of self-made rutong recipe in preventing and treating recurrence and metastasis of breast cancer patients. Methods: A total of 109 patients with breast cancer after surgery were retrospectively analyzed. Fifty-seven patients in the treatment group and 52 in the control group were divided into two groups according to their medication: the overall survival rate (OS) , Disease-free survival (DFS), quality of life. Results: The two groups of patients had homogeneity of variance with respect to baseline data such as age, menstrual status, pathological type, clinical stage, lymph node metastasis, hormone receptor expression and Her-2 expression (P < 0.05). The follow-up time ranged from 13 to 126 months and the median follow-up time was 61 months. The 3-year DFS rates of the two groups were 91.4% and 68.4%, respectively, with significant difference (P <0.01). The 3-year OS rates were 100.0% and 97.1% (P> 0.05). The 5-year DFS rates were 63.6% and 36.8%, respectively, with statistical significance (P <0.01). The 5-year OS rates were 93.5% and 62.5%, respectively, with significant difference (P <0.01). The quality of life was scored by FACT-B, and the post-treatment function (P <0.01); some functions of the control group were significantly improved than before treatment, the difference was statistically significant (P <0.01); after treatment, the two groups of functional score comparison, the difference was statistically significant The difference was statistically significant (P <0.01). Conclusion: Milk formula with Western medicine in the treatment of postoperative patients with breast cancer can further prolong the overall survival and disease-free survival time and improve patient quality of life.